In anaphylaxis, most fatalities occur within what time frame after exposure?

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Multiple Choice

In anaphylaxis, most fatalities occur within what time frame after exposure?

Anaphylaxis can progress extremely quickly because the release of mediators causes airway swelling, bronchospasm, and profound low blood pressure within minutes to an hour after exposure. Because of that rapid course, most fatalities occur within the first hour after exposure if the reaction isn’t treated promptly. This is why immediate administration of epinephrine is the most crucial first step in management. The other time frames are not consistent with the typical lethal window, and fatalities are not limited to after a second exposure—the reaction can be life-threatening on the first clear exposure when sensitization exists and is often rapid if not treated.

Anaphylaxis can progress extremely quickly because the release of mediators causes airway swelling, bronchospasm, and profound low blood pressure within minutes to an hour after exposure. Because of that rapid course, most fatalities occur within the first hour after exposure if the reaction isn’t treated promptly. This is why immediate administration of epinephrine is the most crucial first step in management. The other time frames are not consistent with the typical lethal window, and fatalities are not limited to after a second exposure—the reaction can be life-threatening on the first clear exposure when sensitization exists and is often rapid if not treated.

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