Which regimen for latent TB is given weekly?

• A. INH daily for 9 months.
• B. INH and RIF daily for three months.
• C. INH and rifapentine weekly for three months.
• D. RIF daily for four months.

Answer: (C)

Treating latent TB often uses regimens chosen for how often you take the medicines, not just how long you take them. The weekly approach combines isoniazid with rifapentine and is given once a week for about 12 weeks (three months). Rifapentine lasts longer in the body than rifampin, which lets you dose less frequently while still effectively suppressing latent bacteria. This schedule is usually delivered with directly observed therapy to help people complete the course. So, this weekly option stands out from daily regimens (such as daily isoniazid for 9 months or daily isoniazid plus rifampin for 3 months) and from the daily rifampin alone for four months.